Les séminaires ont lieu les mardis à 14h dans l'amphithéâtre du CGFB (sauf avis contraire)


Prochain Séminaire :

10 Décembre 2019 : Laura Cantini (ENS, Paris)

TITRE : Network-guided integration of multi-omics data: towards a comprehensive view of cancer
Résumé :

Cancer is a global health issue with a mortality rate that is expected to rise by about 70% over the next 2 decades (World Health Organization). Despite the significant breakthroughs in its understanding, prevention, and treatment, cancer’s complexity slows the quest for its cure. The advent of high-throughput technologies has provided the possibility to gather a comprehensive molecular picture of this disease by allowing the detailed characterization of thousands of tumors at multiple molecular levels (“multi-omics”). The current main challenge is to translate this wealth of information into actionable knowledge about the pathogenesis of this disease.

In this talk I will give three examples of how the integration of multiple omics data can reveal new insights about cancer. First, I will show that combining microRNA and mRNA expression data we can identify new regulatory mechanisms underlying colorectal cancer subtypes. Second, I will prove that multiplex networks, a trending topic in network theory, are very well suited for the joint integration of multi-omics data. Third, I will show that by combining the results of matrix factorization across 14 independent transcriptomic datasets we can reconstruct the landscape of those pathways involved in the the different subtypes of colorectal cancer.


Séminaires à venir

4 Février 2020 - Alexandra Calteau (LABGeM bioinformatics team of the UMR 8030 Genomics Metabolics, research structure of Genoscope )

11 Février 2020 - Anais Baudot (Marseille Medical Genetics, Aix-Marseille Université)

Séminaires passés

22 Octobre 2019  - Guillaume Bernard (Sorbonne university, MNHN, Paris)

Next-generation phylogenomics: alignment-free approaches, sequence similarity networks and more.


8 Octobre 2019 - Laurent Brehelin (LIRMM, Montpellier)

Probing transcriptional regulation with statistical models


21 Mai 2019 - Eduardo Rocha (Institut Pasteur)

Horizontal gene transfer: from acquisition to functional innovation


7 Mai 2019 - Florian Thibord (UPMC Université Paris 6)

Alignement des données miRseq


26 Mars 2019 - Julien Chiquet (AgroParisTech)

A collection of Poisson lognormal models for multivariate analysis of count data


19 Février 2019 - Magali Champion (Université Paris Descartes)

AMARETTO: Multi-omics data fusion for cancer data


8 Janvier 2019 - Warren Francis (University of Southern Denmark)

Comparative genomics and the nature of placozoan species


29 Novembre 2018 - Antonio Marco (University of Essex, UK), TBA

On sex, mothers and microRNA


11 Novembre 2018 - Clovis Galliez (Université de Grenoble)

Making sense of the metagenomics mixture: identifying bacterial hosts from phage sequences and binning billions of contigs